I'm not a big fan of Oprah, anyway, and I didn't see the show where she lambasted James Frey.
I did read the book - A Million Little Pieces - though. I thought it was excellent - powerful, raw, compelling. It matters less than a whit to me if some of the details were not strictly factual. I don't see how it compromises the message of the book in any way. If it were entirely fictional it would be no less powerful.
I think it's a shame that Oprah couldn't say the same.